Kidney disease is affecting an increasing number of people worldwide. There is still much to learn about how cells communicate during development, injury, and regeneration. By understanding this communication better, we can uncover which processes are crucial for a fully functioning kidney. This research focuses on deciphering the inter-cellular language between different types of kidney cells.
Impact
This research advances scientific knowledge by unraveling the complex communication between kidney cells, deepening our understanding of the processes that drive kidney development, regeneration and repair. The gained insights could pave the way for new therapeutic strategiesto prevent and treat kidney disease, ultimately improving patient outcomes.
reNEW research
Cellular communication is complex and multi-layered. We have gathered spatial datasets at the (epi-)genetic, metabolic and protein levels, and are now focusing on analzying, integrating and visualizing these levels. This way of multi-layerd analysis is crucial for interpreting the data and advancing our understanding of the inter-cellular language during kidney regeneration.
Image description
This image portrays the journey of regeneration. Based on gene expression data, the healthy cellular landscape on the left contrasts with the regenerating landscape on the right, highlighting changes in the cellular environment.
Credits
Rosalie Rietjens, Rabelink lab, reNEW Leiden, The Netherlands.
