The Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW) at the Murdoch Children’s Research Institute is looking for a Research Officer in the Blood Program.
Who We Are
At Murdoch Children’s Research Institute, we share a powerful vision; to re-imagine the future of child health. We are the home to many life-changing scientific discoveries. We believe that no question is too impossible to try and answer. We are renowned for our cutting-edge focus on early interventions, improved diagnosis, prevention, and development of potential cures. Our success is founded on a philosophy of collaboration through a multi-disciplinary approach to solving the toughest questions in child health. Murdoch Children’s is committed to creating a culture of inclusivity, equity and respect that celebrates and values the diverse backgrounds and experiences of our people. We strive to foster a positive working environment that is underpinned by equal opportunity for all and consideration for the diverse voices of our people and the communities we serve. Murdoch Children’s is a proud member of the Australian Network on Disability and is a committed subscriber to Science Australia Gender Equity (SAGE) and its principles.
The Blood Program with the reNEW centre for Stem Cell Medicine at MCRI focusses on the generation of human blood cells from pluripotent stem cells (PSCs), with the key objective of developing new treatments for currently intractable diseases of the human blood system. The program encompasses three research groups (Blood Development, Blood Disease and Immune Development) that use PSCs to investigate the development of blood cells, their potential for creating novel therapies, and their involvement in human disease.
This position is for a junior postdoctoral fellow with experience in both pluripotent stem cell differentiation to haematopoietic lineages and expertise in the bioinformatic analysis of differentiating haematopoietic populations. They will explore the transcriptional and chromatin responses to cytokine administration and withdrawal at different stages during the in vitro differentiation of human pluripotent stem cells to haemogenic endothelium and haematopoietic stem and progenitor cells. It is envisaged that the project could also include the dissection of the process by which specific lineages develop from a stem cell pool or comparisons between normal differentiation and cancer or bone marrow failure.
It is anticipated that the work done will contribute to the ability to generate cells for therapy or to model haematopoietic disease with a view to developing new therapeutic strategies.
- Experience in culture and haematopoietic differentiation of pluripotent stem cells
- PhD qualification in science or related discipline
- Demonstrated capacity to work independently and collaboratively in a team environment
- Excellent time management, organisational and analytical problem-solving skills
Application close: 6 April 2023.
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