Postdoc position: Development of an in vitro Corneal Endothelium Model

Are you an enthusiastic postdoctoral researcher with a passion for bioengineering and stem cell technology? Join our team at LUMC to develop cutting-edge in vitro models for the corneal endothelium of the eye. If you’re excited about multidisciplinary research and advancing regenerative medicine, then we would love to meet you!

About your workplace
You will be part of the OtoBiology Leiden research group at the Department of Otorhinolaryngology, led by Dr. Heiko Locher. Additionally, you will be part of the reNEW consortium and will work in a new research building at the Leiden Bio Science Park together with other stem cell researchers. Here we share labs and office space with renowned research groups. This will be a large, perfect learning and research environment with state-of-the-art facilities and techniques. In addition, the large network of international researchers increases potential future career steps. Collaboration with other research groups focusing on similar models in different organ systems is expected.

About your role
As a postdoctoral researcher, you are responsible for developing in vitro model systems to investigate and characterize the cornea. You will be involved in research aimed at discovering and designing platforms for corneal endothelium.

The potential use of induced pluripotent stem cell (iPSC)-derived corneal endothelium for transplantation offers promising opportunities for treating corneal endothelial disorders. However, to ensure successful and safe transplantation, it is essential to thoroughly assess tissue functionality. Merely observing specific morphology and proteins is inadequate; a comprehensive evaluation of function is necessary to truly mimic in vivo endothelial tissue.

You will develop an assay to assess two key features of cultured corneal endothelial cells: monolayer barrier and pump function. You are a motivated individual with a solid background in bioengineering, stem cell technology, and organ-on-chip systems, interested in multidisciplinary research. This fully funded 2-year postdoc position will be integrated into the OtoBiology Leiden research group, located at Leiden University Medical Center (LUMC) and a partner in the reNEW consortium, in close collaboration with Dr. Vanessa LaPointe’s group at the MERLN Institute for Technology-Inspired Regenerative Medicine at Maastricht University.
[Module 5: About you]

About you

  • You are an ambitious, proactive, and creative thinker with a PhD in Biomedical Technology or similar field, eager to engage in a challenging project at the intersection of engineering and biology.
  • Experience with read-out assays to investigate cellular functions is highly valued, but familiarity with the eye is not required.
  • The ability to work both independently and as part of a team.
  • Interest in (partially) supervising a PhD candidate.
  • Proficiency in scientific English, including listening, speaking, reading, and writing, is essential. Knowledge of the Dutch language is not mandatory.

Interested or having questions? You can find more information and apply via the link below.

Applications are open until July 8th. Postdoc Position: Development of an In Vitro Corneal Endothelium Model | LUMC