Are you ambitious and interested in research in the field of stem cells? Do you want to learn everything about kidney organoids, including how to generate and use them as a tool to study disease and drug toxicity? Then don’t hesitate to apply!
About your workplace
You will have a position in the Leiden University Medical Center (LUMC). The project is a collaboration between the LUMC and the Leiden Academic Center for Drug Research (LACDR). At LUMC you will be part of the nephrology department, focusing on disease modelling within the renal regenerative medicine group of prof. AJ Rabelink. In addition you will be part of reNEW, an international research center for stem cell medicine (www.renew.science). This opens the door to collaboration and exchange opportunities with our partner institutes in Copenhagen and Melbourne. You will be working in the brand new labs at Mirai House, located at the Leiden Bio Science Park, where over a hundred stem cell researchers are clustered.
About your role
In this PhD project, you will generate kidney organoids derived from pluripotent stem cells to model renal tubular disease and test renal drug toxicity. Generating organoids derived from fluorescent reporter lines as well as producing tubules-on-a-chip are part of the 4-year project. You will combine the use of basic immunofluorescence imaging with advanced techniques such as single cell transcriptomics and metabolomics.
- You are an excellent and ambitious candidate with an MSc degree in biomedical or life sciences.
- You have experience in (stem) cell culture and basic laboratory techniques such as PCR, immunohistochemistry and CRISPR Cas9 gene editing.
- You are experienced, or interested to become experienced, in the analysis of multi-omics analysis and programming
- It is important that you are fluent in both written and spoken English
Interested? Send your CV and motivation letter to Siebe Spijker (H.S.Spijker@lumc.nl). Also don’t hesitate to contact Siebe if you have any questions!