The brain has many complex networks, like a city’s interconnected metro system. We work on creating 3D models that mimic this complexity, called brain organoids. Using stem cells derived from patient samples, our goal is to create brain organoids to teach us about patient-specific disease onset and progression, as well as the complex networks of rare neurological conditions.
Impact
Brain organoid models that replicate the brain’s complexity are essential in discovering disease mechanisms, which assists in the production of therapies. We study Alexander disease (AxD), a progressive and fatal childhood disease, with no effective treatment. Through patient stem cell-derived AxD brain organoids, we learn how the disease originates, progresses, and affects brain development. This knowledge brings us closer to the implementation of precise and effective therapies.
reNEW research
Our lab has generated a variety of brain organoid models that represent many regions and complexities of the human brain. Utilizing these high-end models, for the first time we can replicate clinical symptoms of Alexander disease within a 3D human system. This demonstrates the power of brain organoid models for delving deeper into the intracacies of neurological disease.
Image description
We see the connecting networks of many brain cells in a brain organoid. In green are neurons, cells that send signals around the body; and pink are astrocytes, the support system of neurons. In blue are the cell nuclei, showing all cells.
Credits
Dr, Kellie Veen, Research Officer, Velasco Lab, reNEW Melbourne.
