IBD affects over 6.8 million people globally, causing recurring gut inflammation and epithelial damage. With no cure available, our research aims to understand how damaged intestinal epithelium reverts to a fetal-like state during repair. By studying how fetal intestinal epithelium matures into its adult form, we seek to uncover key mechanisms of gut regeneration, paving the way for new therapeutic approaches.
Impact
Our research focuses on understanding intestinal regeneration to develop new treatments for conditions like IBD that damage the intestinal epithelium. By uncovering these mechanisms, we aim to enhance the body’s natural repair processes, promoting faster recovery after injury. This work could significantly improve treatments for millions affected by IBD, offering hope for better therapies and potential cures.
reNEW research
Prof. Kim Jensen lab focuses on using adult epithelial stem cell approaches to advance drug development and cell therapies aimed at enhancing the quality of life for patients with IBD. Through our screening efforts, we have identified several novel mechanisms that play a crucial role in tissue regeneration, offering strong potential for future therapeutic applications.
Image description
Image of immature fetal intestinal epithelium undergoing maturation, with a few red-colored cells indicating the presence of Paneth cells—the earliest signs of epithelial maturation.
Credits
Kadi Lõhmussaar, PhD – postdoctoral researcher (Kim Jensen lab, reNEW Copenhagen).
