Spatial transcriptomics (ST) is a novel, disruptive technology that permits exploration of gene regulatory networks with spatial and temporal resolution. The insight provided by ST platforms promises to shed new light on developmental biology across an array of tissue types including organoids. In particular, organoids offer the opportunity to model development and disease while overcoming many of the limitations of animal models or 2D cell cultures. As organoids can be cultured from genetically engineered stem cell and patient cell lines, they permit the detailed analysis of the transcriptional perturbations that underlie disease pathogenesis. More specifically, organoids display 3D organisation in vitro, making them prime candidates for exploration with ST. We applied STOmics, the first ST platform to offer sub-cellular resolution while capturing transcriptome-wide information, to profile an array of organoids including: brain, heart, lung, cartilage, blood and kidney (the ones displayed in the image).