Hematopoitec stem cells (HSCs) give rise to blood stem cells which will lead to developing different types of cells within the blood stream. In our lab the main focus of the research is to identify key pathways that is important in correctly developing these stem cells in their surrounding environment during the embryonic stage to then use in life saving blood diseases.
Impact
Hematopoitec stem cell (HSC) transplants will be very important for patients with blood bone disease or bone marrow failure. They will help to replace blood-forming cells in the bone marrow that have been destroyed from a disease with healthy stem cells. In our mouse studies, these cells then develop into new bone marrow and produce healthy blood cells. Another advantage of HSC transplants is that we will one day generate stem cells from the patients to avoid any donor shortages.
reNEW research
We are working on this.
Image description
The big red cell at the bottom is a part of the orgonoid that will mature to prodiuce blood. The structures that runs out from the orgonoid boby are called endothelium that will then give rise to blood cells. The red that is indicated in the picture is the representation of the gene that is expressed in the blood development.
Credits
Hasindu Edirisinghe – Research Assistant.
Elizabeth Ng, Andrew Elefanty lab, Melbourne.
